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GINBEX 120ml/240ml Sugar Free

GINBEX (Ginkgo biloba)
 
INTRODUCTION:
The Ginkgo biloba is the oldest living tree specie, estimated to be 150-200 million years old. It has got characteristic fan shaped bilobed leaves. The extract of Ginkgo biloba was first brought to Europe in the 1700`s and now it is one of the most commonly prescribed drug in France and Germany. Now it is also popular in the United state and parts of the world. It is one of the most well researched herb in the world. Ginkgo represent one of the most studied and commonly used herbal remedies in the world. The National Health Interview Survey found that ginkgo was the seventh most popular natural product in the United States in 2007. Over 400 clinical trials have been performed looking at a
variety of medicinal properties and clinical use.
A number of clinical studies have given evidence that Ginkgo prevents and benefits many problems throughout the entire body especially due to neuroprotective  properties and ability to aid circulatory problem in elderly.
 
CONSTITUENTS:
This standardized extract of Ginkgo biloba contains 2 active constituents I,e. flavonoid Glucosides 42% namely Kaemferol, Quercetin and Isorhamentin, and Terpene Lactones 6% namely Ginkgolides A, B, C, and Bilobalides. The medical benefit of Ginkgo depends upon the balance of these two active compounds.
 
PHARMACODYNAMICS:
Generally works by increasing blood flow to the brain and throughout the body`s of blood vessel. This leads to improved supply of blood and oxygen to the organ systems. Studies have shown that GBE stimulates release of two potent vasodilator from the arterial endothelium-derived relaxing factor (EDRF). The effects shown to increase total perfusion by a significant percentage.
The flavonoid component f Ginkgo acts as antioxidant by snatching free radicals. This result is reduced lipid per oxidation and protects against cell membrane damage. This antioxidant properity has beneficial effects particularly in brain, retina of the eye and cardiovascular system. The Ginkgolide component in terpene lactone compete with and inhibit Platelet Activating Factor (PAF) and thus prevent against platelet aggregation. This improves blood flow especially in brain as well as in peripheral circulation or extremities. Biobalides are thought to stimulate regeneration of damaged nerve cells. These are therefore responsible for improving memory and mental function.
 
INDICATIONS:
1.    Cerebrovascular insufficiency impairment and it is functional manifestation i.e. Congnitive disorders involving memory. Attention, awareness, etc. for example, Alzheimer`s disease, Dementia, specially associated with aging (senile dementia).
2.    In addition it is also helpful in Tinnitus, Vertigo, Menieres`s disease and Macular Degeneration.
3.    Depression, resistant to standard Antidepressants like trocyclic antidepressants.
4.    Peripteral vascular disease e.g. Diabetic foot, etc.
5.    Sexual dysfunctions of vascular Origin Especially secondary to use of antidepressants.
 
DOSAGE AND ADMONISTRATION:
The general recommended daily dose range is 120-240 mg in divided dose. However in most of The conditions the higher dose i.e. 240mg to be taken as 1 tsf b.i.d. is preferred for better result based on the disease and its severity, it should be used as prescribed by the physician. Optimal duration of treatment has not been determined most patient require months before significant effects are felt in chronic conditions the Ginbex administrated for at least 4-8 weeks evaluation of efficacy, it is proved that the longer the treatment in continued the more obvious and last result are.
 
CHILDREN:
Ginbex in not recommended in children under 2 years age. As studied have been not conducted in children, use above 2 years should only be done after consulting the physician.
 
FERTILITY PREGNANCY:
In experimental no indication were found for embryo toxic, mutagenic or teratogenic effects. Oral administration or up to 1600mg/kg/ day to rabbits did not produced teratogentic effects. In addition reproduction was not effected. Human data on adverse of Ginkgo preparation with respect to fertility, pregnancy and lactation is not available. Ginbex should only be used during the first trimester of pregnancy if this is justified by the anticipated therapeutic benefit up to now there has been no evidence of any increase in the risk of malformation in humans.
 
CONTRAINDCATIONS:
Ginbex should be avoided in patient with know hypersensitivity to the drug`s ingredients. Should not be used in patient with Hemophilia or other disorders.
 
DRUG INTERACTIONS:
The combined se with aspirin has been reported to cause subdural hematoma in some individuals. Use with aspirin and other anticoagulants e.g. warfarine should therefore be avoided or done with extreme care.
 
ADVERSE EFFECTS:
Ginkgo biloba extract appears to be well tolerated. The occasinally reported side effects are gastrointestinal including nausea, vomiting, increased salivation, loss of appetite and heartburn. These effects are usually mild and transient.
 
PRESENTATION
1.    GINBEX is available as syrup 120ml and 240ml containing EGB 761as 120mg / 5ml in pet bottle and special heat and light resistant thermo pore packing.
2.    Ginbex is also available in capsules, each capsule contain 120 mg of EBG in plastic bottle of 30 capsule packins.