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D.Drop Vitamin D3 Injection

D-Drop 5mg Injection
Oral ampoule\IM Ampoule

Vitamin D3
(cholecalciferol)

COMPOSITION
Each ml contains Vitamin D3 USP……5mg

DESCRIPTION: Vitamin D3 is a fat-soluble vitamin that is essential for maintaining normal calcium metabolism.
PHARMACOLOGY:
Pharmacodynamics vitamin D3  (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight or it can be obtained from diet. When exposure to UVB radiation is  insufficient for synthesis of adequate amounts of Vitamin D3 in skin, adequate intake of Vitamin D3 from diet in essential for health. most of action of Vitamin D3 are medicated though nuclear transcription factor known as the Vitamin D receptor (VDR).

PHARMACOKINETICS:
Vitamin D3 is well absorbed from the gastrointestinal tract. The presence of bile is essential for the adequate intestinal adsorption. Absorption may be decreased in patients with decreased fat absorption. Vitamin D3 and its metabolite circulate in blood bound to specific alpha globulin. Vitamin D3 can be stored  in muscle and adipose tissue for a long periods of time. It is slowly released from such storage sites and from the skin where it is formed in the presence of sunlight or UVB. Vitamin D3 has a slow onset and longer duration of action. Vitamin D3 compounds and their metabolites are excreted mainly in the bile and faeces with only small amount appearing in the urine. There is some enterohepatic recycling but it is considered to have negligible contribution to Vitamin D3  status certain Vitamin D3 substances may be distributed into breast milk.

INDICATIONS:
D-Drop is indicated in prevention & treatment of Vitamin D3 deficiencies. It is involved in bone fixation oc calcium. D-Drop promotes strong bones & teeth, supports healthy immune system, promotes muscle strength, defends against cancer, maintains cardiovascular health, aids in proper digestion  food absorption, promotes healthy mood, regulates sleep, maintains eye  ear health, knees hair  skin healthy, aids in weight management, slows the aging process supports healthy endocrine function and maintains respiratory ( prevents asthma cold & flu) & reproductive health.

CONTRAINDIATIONS:
The drug must not be used in the following cases
* Hypersensitivity to any of the ingredients mainly to the Vitamin D3
* Hypercaicemia (abnormally high levels of blood calcium).
* Hypercalciuria ( excessive urinary elimiration of calcium).
* Kidney stones.

Dosage & Administration:
Nursed infants or infants not receiving Vitamin D enriched milk or young children upto 5 years of age.
1 ampoule (5mg) every 6 months.
Adolescents: 1 ampoule (5 mg)grom 6th or 7th months during winter.
Pregnancy: 1\2 ampoule (2.5mg)from 6th or 7th month of pregnancy.
Elderly: 1\2 ampoule (2.5 mg) every 3 months deficiency. 1 ampoule (5mg) which can be renewed every 1 to 6 months.

SPECIAL INSTRUCTION TO PHYSICIAN:
If high or repeated doses of Vitamin D3 are administrated or if high dose of calcium are associated. It is necessary to monitor calcium levels in blood and urine.

Over Dosage:
Overdose symptoms may include headache, weakness, drowness dry mouth nausea vomiting constipation muscle or bone pain. metallic taste in the mouth, weight loss. Itchy skin, changes in heart rate, confusion, unusal thoughts or behavior, sever pain in your upper stomach spreding to your back and fainting. Treatment of Vitamin D3 toxicity me include stopping Vitamin D supplements intake and restricting calciu7m intake as well as taking medication, in severe cases, hospitalization may be necessary.

STORAGE \ PRECAUTIONS:
Do not refrigerator. Injection  should not be used if the ampoule is leaking or it contains undissolved particles.store in cool. Dry and dark place blow 25 c. keep all medicine out of the reach of children.